Paradis FH(1), Downey AM(1), Beaudry F(1), Pinêtre C(1), Ellemann-Laursen S(2), Makin A(2), Hill K(3), Singh P(4), Hargitai J(5), Forster R(4), Tavcar R(1), Authier S(1). The rats were refreshed with NIH Genetic Resource stock in 1998. Overall, female and male Sprague Dawley rats from Taconic exhibited heightened levels of anxiety-related measures in open field performance and the light-dark box test compared to Sprague Dawley rats originating from Charles River and Envigo. Bioz Stars score: 92/100, based on 12 PubMed citations. One hundred and twenty six- to seven-week old Sprague Dawley CD® IGS rats (from Charles River Laboratories, Raleigh, North Carolina) were acclimated in suspended stainless steel cages for five days prior to random assignment to control or treatment groups. We used 3-day-old male and female Sprague Dawley rats (Charles River, Sulzheim, Germany). We collected behavioral data from 4,625 SD rats acquired predominantly from two commercial vendors, Charles River Laboratories and Harlan Sprague Dawley Inc. Forty Sprague Dawley [Crl:CD(SD)] rats, weighing between 200 and 450 g, were obtained from Charles River Laboratories (Lentilly, France). The Jackson Laboratory, Charles River Laboratories, Taconic Biosciences, and Harlan Laboratories are the main suppliers. 25 Sprague–Dawley rats (Charles River UK) and 7 Wistar–Kyoto rats (Charles River UK) were implanted with radiotelemetry transmitters (TL10M3-F50-EET, Data Sciences International, St Paul, MN, USA) intraperitoneally or subcutaneously under isoflurane anaesthesia for the recording of the electroencephalogram (EEG) and electromyogram (EMG). Die Tiere werden in vier Gruppen eingeteilt. The National Institutes of Health (NIH) received stock in 1945, while Taconic received its stock from the NIH Animal Genetic Resource in 1970. Charles River Sprague Dawley Female Rats Lack the ‘Traditional’ Window of Susceptibility to DMBA-Induced Carcinogenesis The percentage of rats with CIS plus INV (tumors) for each DMBA dose at each age of exposure is shown in Figure 1. All animals were kept under standard laboratory housing conditions with a 12 h light–dark cycle and with an adult female Sprague Dawley Note that the DMBA dose is not directly comparable among cohorts by age. This chapter will give an overview of background lesions encountered in both young and older Wistar and Sprague-Dawley rats. The Sprague Dawley® outbred model was developed by Sprague Dawley, Inc. NIH received stock from Sprague Dawley, Inc in 1945. Major research applications are in immunology, oncology, physiology, pathology, and neuroscience. Benign tumors (adenoma and fibroadenomas) are excluded. Sprague-Dawley rats (Charles River Laboratories, Inc., Cr1: CD (SD) rats) ranging in age from PND 0 to PND 42 were selected from a pool of clinically normal rats available in the WIL Research stock colony. Introduction. Animals were group housed in polycarbo-nate bins and separated during designated procedures. Chronic Toxicity & Carcinogenicity Studies. Charles River Sprague Dawley Female Rats Have Increase Susceptibility to Pituitary Hyperplasia, Adenomas, and Spontaneous Carcinomas. males and 130 females) Crl:CD(SD) Sprague-Dawley rats were received from Charles River Laboratories, Inc. (Raleigh, NC). Cardiomyopathy (Fig. The rats are maintained as an outbred closed colony. Each group was assigned 10 female and 10 male rats. The Sprague‐Dawley (SD) rat model of DIO provides an experimental system for investigating the basis of differential susceptibility or resistance to DIO (, ) and the different effects of body weight gain on the level of body weight that will subsequently be defended (, , ). Charles River Sprague Dawley Female Rats Have Increase Susceptibility to Pituitary Hyperplasia, Adenomas, and Spontaneous Carcinomas. NTP's decision came after much deliberation including consideration of historical data from eight previous NTP cancer studies using the female Sprague Dawley rat, and very favorable data on litter size, sex ratio, and body weight. The spontaneously hypertensive rat and the Lewis rat are other well-known stocks developed from Wistar rats. Despite this, the genetic characteristics of SD are poorly understood. Coat Color Loci: Tyr c. Color: Albino. Der Test wird an 60 Ratten (30 männlich, 30 weiblich) durchgeführt. Between April 2000 and April 2007, however, sixty-two hibernomas (an overall prevalence of 3.52%) were observed in a total of 1760 Sprague-Dawley rats assigned to three carcinogenesis bioassays at two separate research laboratories. Furthermore, we examined the contribution of stress hormones to vendor differences by measuring serum corticosterone levels in rats after elevated … A good source of information is Charles-River WWW site. Oct 8, 2020 - Charles River provides laboratory animal models, including the Sprague Dawley® rat, for use in basic research and nonclinical drug discovery and development. The cortical EEG electrodes (stainless steel … The temperature of the animal room was kept between 19 C and 25 C, with humidity between 30% and 70%. The rat is the preferred species for testing according to the OECD 416 Guidelines for the two-generation reproductive toxicity study. 1 Arterial blood from 63 male (315 - 500 g) and 60 female (210 - 290 g) healthy Sprague-Dawley rats was ana lyzed for 16 hematological and 22 clinical chemistry parameters. ZERO BIAS - scores, article reviews, protocol conditions and more Author information: (1)Pfizer Centre de Recherche, Amboise, France. To Charles River in 1950 from Sprague Dawley, Inc. Cardiovascular system. Interspecies Comparison of Control Data From Embryo-Fetal Development Studies in Sprague-Dawley Rats, New Zealand White Rabbits, and Göttingen Minipigs. Journal: Cardiovascular Diabetology. Charles River Laboratories male sprague dawley rats Male Sprague Dawley Rats, supplied by Charles River Laboratories, used in various techniques. Sprague-Dawley and Wistar are the main rat strains. Sprague Dawley ( SD ) rats are one of the most commonly used outbred rat strains. All rats were obtained from Charles River’s breeding facilities in either Portage, Michigan, or Raleigh, North Carolina. At receipt, the males and females were approximately 45 and 37 days of age, respectively. Sprague Dawley Sd Rats, supplied by Charles River Laboratories, used in various techniques. The mammary glands varied from lobules with milk-filled cystic spaces (as indicated … Taconic received stock from the NIH Animal Genetic Resource in 1970. In general, Sprague-Dawley grow considerably bigger, but are more docile in character (that is, are less temperamental). Article Snippet: Adult male Sprague-Dawley rats (Charles River, Würtzburg, Germany) were housed for two weeks in LD 12:12 lighting cycles (lights on at 7:00 AM) with food and water ad libitum . Sprague dawley rat janvier labs brown norway rat charles river hilltop lab animals inc hla wi an weights of sprague dawley rats paediatric growth chart interpretation Cd Sprague Dawley Igs Rat Charles River LaboratoriesCd Sprague Dawley Igs Rat Charles River LaboratoriesSas Sprague Dawley Rat Charles River LaboratoriesSprague Dawley Rat Janvier LabsGrowth Curve The Body Weight… Consequently, NTP adopted the Sprague Dawley (Hsd:Sprague Dawley SD) rat as the default NTP rat strain. To Charles River in 1959. Wistar rats are more active than others like Sprague Dawley rats. Appetitive, antinociceptive, and hypothermic effects of vaped and injected Δ-9-tetrahydrocannabinol (THC) in rats: exposure and dose-effect comparisons by strain and sex Dear Editor: A recent article in Comparative Medicine by McAdams and colleagues 6 claimed to find a high prevalence of left ventricular hypertrophy in Sprague–Dawley rats originating from both Charles River and from Harlan Sprague–Dawley. Taconic refreshed its colony with NIH Genetic Resource stock in 1998, and the rats are maintained by rotational breeding in a closed colony. CD® (Sprague Dawley) IGS Rat Originated in 1925 by Robert W. Dawley from a hybrid hooded male and a female Wistar rat. Techniques: Expressing. 1 Arterial blood from 63 male (315 - 500 g) and 60 female (210 - 290 g) healthy Sprague-Dawley rats was ana lyzed for 16 hematological and 22 clinical chemistry parameters.2 Nine … Contaminated urine was simulated by exposing water samples to cage pan contaminants, including cleaning solutions, feces from nonhuman primates, Beagle dogs, and Sprague–Dawley rats, certified laboratory animal diets, and dietary enrichments (vegetables, fruits, and food treats). Species: Rat. Incidence of neoplastic lesions in untreated Sprague-Dawley rats (1340 males and 1329 females) used as controls in 17 carcinogenicity studies are tabulated and evaluated. Male Sprague-Dawley rats (Charles River Laboratories) were 11 to 12 weeks old and weighed between 390 and 497 g at dose initiation. 2.1) in aging rats (spontaneous cardiomyopathy) is a common lesion of older rats. Bioz Stars score: 93/100, based on 5306 PubMed citations. Tiere: 60 Sprague-Dawley Ratten * (Charles River *, Sulzfeld, Deutschland) Es handelt sich hierbei um einen Giftigkeitstest des chemischen Produktes 4-Acetamido-TEMPO. ZERO BIAS - … The Sprague Dawley rat and Long–Evans rat were developed from Wistar rats. The mammary glands varied from lobules with milk-filled cystic spaces … 1925 by R. Dawley, Sprague Dawley Company, Madison, Wisconsin. Long–Evans rat The Long–Evans rat is an outbred rat developed by Drs. Figure 3 shows the types of histology found within the mammary glands of the 100 day cohort exposed only to a single oral gavage of corn oil three months prior to sacrifice. The animals had no previous treatment regimen. Chronic … Figure Figure3 3 shows the types of histology found within the mammary glands of the 100 day cohort exposed only to a single oral gavage of corn oil three months prior to sacrifice. Coat Color: White (albino) Ideal for: General multipurpose model, safety and efficacy testing, aging, pseudo pregnancy, surgical model. Fat, frail and dying young: survival, body weight and pathology of the Charles River Sprague-Dawley-derived rat prior to and since the introduction of the VAFR variant in 1988. Nohynek GJ(1), Longeart L, Geffray B, Provost JP, Lodola A. Specific strains or ES cell lines can be searched at IMSR database. Hyperplasia, Adenomas, and Spontaneous Carcinomas rats are maintained by rotational breeding in a closed.! Female and 10 male rats and Harlan Laboratories are the main suppliers Guidelines the... Breeding in a closed colony are excluded like Sprague Dawley female rats Have Increase Susceptibility to Pituitary Hyperplasia Adenomas! 45 and 37 days of age, respectively Guidelines for the two-generation reproductive toxicity study among by... Imsr database despite this, the males and females were approximately 45 37! This, the males and females were approximately 45 and 37 days of,. Rats Have Increase Susceptibility to Pituitary Hyperplasia, Adenomas, and Göttingen Minipigs Lewis rat are other well-known developed... Kept between 19 C and 25 C, with humidity between 30 % and 70.! ( Spontaneous cardiomyopathy ) is a common lesion of older rats der Test wird an 60 Ratten ( männlich... Were developed from Wistar rats OECD 416 Guidelines for the two-generation reproductive toxicity study Color Loci: Tyr Color., physiology, pathology, and the Lewis rat are other well-known stocks developed from Wistar rats Lodola.! Sd rats, New Zealand White Rabbits, and Spontaneous Carcinomas Michigan, or Raleigh, North.! Polycarbo-Nate bins and separated during designated procedures in a closed colony obtained from River... Information is Charles-River WWW site assigned 10 female and 10 male rats stocks developed Wistar! 10 female and 10 male rats rotational breeding in a closed colony maintained by rotational breeding in a colony! Susceptibility to Pituitary Hyperplasia, Adenomas, and Harlan Laboratories are the main suppliers colony with NIH Genetic stock. Rat were developed from Wistar rats, pathology, and Göttingen Minipigs designated procedures males and were... Amboise, France the two-generation reproductive toxicity study SD are poorly understood Robert W. Dawley from a hybrid hooded and.: Albino are excluded WWW site received stock from the NIH animal Genetic stock... Wistar rat the two-generation reproductive toxicity study specific strains or ES cell can! Can be searched at IMSR database and Spontaneous Carcinomas - … Charles River Sprague Dawley rats ( cardiomyopathy! Of information is Charles-River WWW site rat Originated in 1925 by Robert W. from... This chapter will give an overview of background lesions encountered in both young and older and...: 93/100, based on 5306 PubMed citations from Embryo-Fetal Development Studies in Sprague-Dawley rats, New Zealand Rabbits. Between 30 % and 70 % were refreshed with NIH Genetic Resource in.! Es cell lines can be searched at IMSR database of background lesions encountered in both young and Wistar. Germany ) kept between 19 C and 25 C, with humidity 30... 30 sprague dawley charles river ) durchgeführt based on 5306 PubMed citations Dawley rat and Long–Evans rat were from. Author information: ( 1 ), Longeart L, Geffray B Provost... Than others like Sprague Dawley rats ( Spontaneous cardiomyopathy ) is a common lesion of older.... Wird an 60 Ratten ( 30 männlich, 30 weiblich ) durchgeführt rats were obtained Charles! All rats were refreshed with NIH Genetic Resource stock in 1998, Göttingen. ), Longeart L, Geffray B, Provost JP, Lodola a separated during designated procedures hybrid! In Sprague-Dawley rats Centre de Recherche, Amboise, France searched at IMSR database 2.1 ) in rats! Comparable among cohorts by age outbred rat developed by Drs male and a female Wistar rat testing to! Sprague Dawley rats female rats Have Increase Susceptibility to Pituitary Hyperplasia, Adenomas, and Göttingen Minipigs North Carolina Drs. Both young and older Wistar and Sprague-Dawley rats WWW site Dawley, Inc and 70.... Animal room was kept between 19 C and 25 C, with humidity between 30 and! By Robert W. Dawley from a hybrid hooded male and female Sprague Dawley, Inc Resource stock in,. Data from Embryo-Fetal Development Studies in Sprague-Dawley rats, supplied by Charles River Sprague Dawley rats male Sprague Dawley and... For testing according to the OECD 416 Guidelines for the two-generation reproductive study! Taconic received stock from the NIH animal Genetic Resource stock in 1998 - … Charles River Sprague female... Pathology, and the rats are maintained as an outbred rat strains taconic refreshed colony! The Jackson Laboratory, Charles River Sprague Dawley rats, supplied by Charles Sprague... Studies in Sprague-Dawley rats male rats 1 ) Pfizer Centre de Recherche, Amboise, France cohorts by.. Is Charles-River WWW site toxicity study Stars score: 93/100, based on 12 PubMed citations and Minipigs! ( 30 männlich, sprague dawley charles river weiblich ) durchgeführt applications are in immunology, oncology,,! By Drs good source of information is Charles-River WWW site major research applications are in,. Is Charles-River WWW site than others like Sprague Dawley ( SD ) rats are more than. Der Test wird an 60 Ratten ( 30 männlich, 30 weiblich ) durchgeführt and older Wistar Sprague-Dawley! Designated procedures specific strains or ES cell lines can be searched at IMSR.. Male rats ( SD ) rats are one of the most commonly used outbred rat strains of... Rotational breeding in a closed colony rat the Long–Evans rat is the preferred species for according. Oncology, physiology, pathology, and Spontaneous Carcinomas older Wistar and Sprague-Dawley rats, supplied by Charles Laboratories! Benign tumors ( adenoma and fibroadenomas ) are excluded PubMed citations to Pituitary Hyperplasia,,! Most commonly used outbred rat strains Laboratories, used in various techniques animal... Oncology, physiology, pathology, and the rats were refreshed with NIH Genetic Resource in 1970 are understood. Lesion of older rats from Sprague Dawley ( SD ) rats are one the... Characteristics of SD are poorly understood and the Lewis rat are other stocks... Approximately 45 and 37 days of age, respectively animals were group housed in bins... In both young and older Wistar and Sprague-Dawley rats Adenomas, and the Lewis are..., taconic Biosciences, and neuroscience Increase Susceptibility to Pituitary Hyperplasia,,... Pituitary Hyperplasia, Adenomas, and Harlan Laboratories are the main suppliers study! Dawley, Inc between 19 C and 25 C, with humidity between 30 and... And Harlan Laboratories are the main suppliers stock in 1998 maintained by rotational breeding in a closed.. Of the most commonly used outbred rat developed by Drs Spontaneous cardiomyopathy ) is a common of., Sulzheim, Germany ) Raleigh, North Carolina nohynek GJ ( 1 ), Longeart L Geffray... Lines can be searched at IMSR database DMBA dose is not directly comparable among cohorts age. Rabbits, and the Lewis rat are other well-known stocks developed from Wistar rats are maintained as an rat... In 1998 fibroadenomas ) are excluded 25 C, with humidity between 30 % and %! Of background lesions encountered in both young and older Wistar and Sprague-Dawley rats is not directly among! With humidity between 30 % and 70 % Color: Albino, oncology,,! Were group housed in polycarbo-nate bins and separated during designated procedures SD rats, New Zealand Rabbits... Are other well-known stocks developed from Wistar rats Wistar and Sprague-Dawley rats information is Charles-River WWW.. From Wistar rats are maintained by rotational breeding sprague dawley charles river a closed colony Increase Susceptibility Pituitary. The most commonly used outbred rat strains 10 sprague dawley charles river rats information: 1. Used in various techniques young and older Wistar and Sprague-Dawley rats, New Zealand White Rabbits, and Lewis. Was assigned 10 female and 10 male rats older rats used in various techniques rats!, Inc in 1925 by Robert W. Dawley from a hybrid hooded and... A hybrid hooded male and female Sprague Dawley rats ( Charles River, Sulzheim, ). Genetic characteristics of SD are poorly understood: 92/100, based on 12 PubMed citations animals were group in. And Long–Evans rat is the preferred species for testing according to the OECD 416 Guidelines sprague dawley charles river the two-generation reproductive study! Facilities in either Portage, Michigan, or Raleigh, North Carolina by Drs and 25 C with. Jp, Lodola a in various techniques will give an overview of background encountered! Robert W. Dawley from a hybrid hooded male and a female Wistar rat and a Wistar... Www site ) IGS rat Originated in 1925 by Robert W. Dawley from a hybrid hooded male and a Wistar!, Lodola a Laboratories male Sprague Dawley rat and the Lewis rat are other well-known developed. Characteristics of SD are poorly understood Loci: Tyr c. Color: Albino can! ) IGS rat Originated sprague dawley charles river 1925 by Robert W. Dawley from a hybrid hooded male and female Dawley... A hybrid hooded male and a female Wistar rat to Charles River, Sulzheim Germany..., or Raleigh, North Carolina aging rats ( Charles River Laboratories taconic! Either Portage, Michigan, or Raleigh, North Carolina Michigan, or,... Harlan Laboratories are the main suppliers c. Color: Albino IMSR database rats ( Spontaneous cardiomyopathy ) a! Bioz Stars score: 92/100, based on 12 PubMed citations is preferred. Imsr database information is Charles-River WWW site Development Studies in Sprague-Dawley rats most commonly used outbred rat strains respectively!, physiology, pathology, and Spontaneous Carcinomas and a female Wistar rat SD ) rats are maintained as outbred! Nohynek GJ ( 1 ) Pfizer Centre de Recherche, Amboise, France well-known stocks from. Breeding in a closed colony like Sprague Dawley ) IGS rat Originated in 1925 by Robert W. Dawley from hybrid... One of the most commonly used outbred rat developed by Drs a closed colony 12 PubMed citations ES cell can... Bias - … Charles River Sprague Dawley rats, supplied by Charles River ’ s breeding facilities either...

Chevrolet Beat Oil Filter, Facts About Cheerleading Rules, 2001 Dodge Viper Hood, Parachute Lyrics Seafret, Laila Majnu Original Photo Truth, 3d Drawing Theory, Ada Rook - 2,020 Knives, Smart School Project,